The availability of a range of laboratory techniques and ovarian stimulation protocols to approach infertility may allow treatment personalization in each couple. The criteria that such personalization can be based on include: the history of infertility in the couple, laboratory data and instrumental examinations findings. Genetics is expected to provide a considerable contribution in defining the 'infertility profile' of the couple as a basis for treatment personalization.

In this online course Manuela Simoni offers a state of the art overview of genetic markers of ovarian response. She introduced the topic, reviewing the methodology of genetic association study and describing the influences of FSH’s and follicle stimulating hormone (FSH) receptors’ genetic polymorphisms on reproductive function physiology. Polymorphisms of FSH receptors, anti-Mullerian hormone (AMH) and AMH receptors and 5,10-methylene-tetrahydrofolate reductase (MTHFR) as markers of response to ovarian stimulation are then reviewed in depth providing updates on data published and proposing future lines of research.

Learning Objectives

By attending this online course, users will update their knowledge of:

• Methodology of genetic association studies
• Role of FSHR polymorphisms in reproductive function physiology
• Achievements in definition of genetic markers of ovarian response