This program is based on the presentation held at the Serono Symposia International Foundation event Treatment Optimisation - Taking Science in Practice that took place in Madrid, Spain, March 5-6, 2006.

Objectives

Upon completion of this program the participant will be able to:

• Diagnostic usefulness of Lhermitte's sign
• Applying natural history data to individual patients
• Understand the strengths and limitations of crossover studies
• How crossover studies can be used to measure the magnitude of treatment effects